Ipamorelin: research overview
What is ipamorelin
Ipamorelin is a synthetic pentapeptide, a compound built from five amino acid residues. It belongs to the family of growth hormone releasing peptides (GHRPs), a group that includes many earlier analogues. The molecule was developed by modifying this structure to improve selectivity in research models.
Ipamorelin has been studied in clinical trials, so the literature describes its physicochemical properties and analytical methods in detail. For a laboratory, that means predictable material to work with and a solid reference point when you plan experiments.
Molecular structure
The sequence Aib-His-D-2Nal-D-Phe-Lys-NH2 contains several elements worth knowing when you interpret results:
- Aib is alpha-aminoisobutyric acid, a non-proteinogenic residue with a simple, branched structure.
- D-2Nal and D-Phe are D-amino acids, mirror images of the standard L-configured residues.
- Lys is lysine, and the NH2 ending marks a C-terminal amide.
The molecular mass is 711.9 g/mol and the formula is C38H49N9O5. These figures let you convert the weight of lyophilized powder into a molar concentration of your solution.
Mechanism described in research
Ipamorelin acts as an agonist of the ghrelin receptor GHSR-1a, which is found among other places in the pituitary gland. In vitro studies have observed stimulation of pituitary cells to release growth hormone (GH). Animal model studies have described selectivity toward the GH axis, with smaller effects on other hormones such as cortisol and prolactin.
Results from one experimental system do not automatically transfer to another model, so a sound research design should include appropriate controls, concentration checks and defined conditions.
Research areas
- Neuroendocrinology and regulation of growth hormone secretion
- Ghrelin signalling and the GHSR-1a receptor
- The GH/IGF-1 axis in in vitro and animal models
- Gastrointestinal motility in preclinical research
- Comparative studies of growth hormone secretagogues
Product specification
| Parameter | Value |
|---|---|
| Name | Ipamorelin |
| CAS number | 170851-70-4 |
| Molecular formula | C38H49N9O5 |
| Molecular mass | 711.9 g/mol |
| Sequence | Aib-His-D-2Nal-D-Phe-Lys-NH2 |
| Form | lyophilized powder |
| Purity | ≥ 99% (HPLC) |
| Sizes | 2 mg, 5 mg, 10 mg |
Laboratory handling
Reconstitution and storage
Store the lyophilized powder at -20 °C, away from moisture and light. Before opening the vial, let it reach room temperature so that moisture does not condense on the substance.
After reconstitution, keep the solution at 2-8 °C and use it according to your experimental plan. Avoid repeated freezing and thawing, because repeated temperature cycles can degrade the sample.
Solvent choice
Laboratory work typically uses water or bacteriostatic water as the solvent. Bacteriostatic water is convenient when a solution is divided into several portions from one vial, because its preservative slows microbial growth. Your research protocol determines the choice of solvent and volume.
Batch quality: HPLC and MS
Each batch is analysed by HPLC, which confirms purity of 99% or higher. Mass spectrometry (MS) confirms the molecular mass of 711.9 g/mol. The batch number ties the measured results to a specific lot.
Ordering and delivery
- Orders placed by 14:00 on a business day ship the same day
- Poland: InPost Parcel Locker, next business day delivery
- Rest of Europe: DPD courier, 2-4 business days
- Free delivery from 75 EUR, 65 GBP or 80 USD
See also
- Quality standards: details of the analyses behind every batch
- Concentration calculator: convert weight into solution concentration
- CJC-1295 no DAC: a secretagogue from the same research axis
- Sermorelin: a GHRH analogue used in studies of the GH axis
- Bacteriostatic water: a solvent for laboratory work
- GHRP-6: a hexapeptide from the GHRP family, studied in growth hormone secretagogue research
- Hexarelin: a GHRP analogue described in studies of the GH axis
