CJC-1295 (no DAC) + Ipamorelin: research overview
CJC-1295 + Ipamorelin is a two-peptide blend in a single vial, made for research. It pairs a GHRH analogue with a GHS-R secretagogue, so both signalling routes of the growth hormone axis can be studied side by side in one model. MOLEVIA offers it as a Research Use Only reagent, in lyophilized form, with purity of 99% or higher for every batch.
What CJC-1295 + Ipamorelin is
The blend contains two components with different structures. CJC-1295 (no DAC) is a synthetic analogue of growth hormone releasing factor, also known as GRF or GHRH. The molecule covers the first 29 amino acid residues of GRF and carries modifications that increase its stability in solution.
Ipamorelin is a short, synthetic pentapeptide. It acts on the GHS-R receptor, the receptor for ghrelin, and the literature describes it as a secretagogue with high selectivity.
The name “no DAC” means the molecule lacks the DAC linker (drug affinity complex), which in the DAC version binds the molecule to blood albumin. The DAC version has been studied in clinical trials, and ipamorelin has also been the subject of clinical research. Both components are therefore well described in the scientific literature.
Mechanism described in research
Both components act on the somatotroph axis, but through different pathways. CJC-1295 (no DAC) activates the GHRH receptor on somatotroph cells of the pituitary gland, which triggers a cAMP-dependent pathway. Ipamorelin acts on the GHS-R receptor and stimulates growth hormone (GH) release, with no clear effect on ACTH or cortisol compared with earlier secretagogues.
In vitro studies have reported increased cAMP levels and GH release in pituitary cell cultures. Animal models have described changes in GH and IGF-1 levels, and combining the two pathways lets you test whether their effects add up.
Results depend on concentration, incubation time and the model used. Every project therefore needs controls, replicates and clearly documented conditions.
Research areas
- Interaction of GHRH and GHS-R signalling in in vitro models
- Growth hormone release in pituitary cell cultures
- The GH/IGF-1 axis in laboratory animal studies
- Comparisons of secretagogues with different mechanisms of action
- Receptor selectivity of GHRH and GHS-R in pharmacology studies
Product specifications
| Parameter | Value |
|---|---|
| Name | CJC-1295 (no DAC) + ipamorelin |
| Components | CJC-1295 (no DAC), ipamorelin |
| Form | lyophilized powder |
| Purity | ≥ 99% (HPLC) |
| Mass | confirmed by mass spectrometry (MS) |
| Available sizes | 5 mg + 5 mg, 10 mg + 10 mg |
Working in the laboratory
Storage
Keep the lyophilized powder at -20 °C, tightly sealed, away from light and moisture. Before opening, let the vial reach room temperature so water vapour does not condense on the powder.
Once reconstituted, store the solution at 2-8 °C. Avoid repeated freezing and thawing, so split larger volumes into aliquots before freezing.
Dissolving and the role of the solvent
Reconstitute according to your research protocol. Bacteriostatic water is the usual solvent in laboratory work and works well as a base for the solution. For peptides with weaker solubility in water, a dilute acetic acid is used as a pre-solvent, and the solution is then brought up with water. Your study plan always determines the choice of solvent and the final concentration.
Batch quality
Every batch is tested by HPLC, which confirms purity of 99% or higher. Mass spectrometry (MS) confirms that the molecular mass matches the expected value. Each batch is identified by its batch number, so each result links to a specific delivery. You can read more about our testing on the quality page.
Related products
- Ipamorelin is a GHS-R secretagogue and a good reference point for comparisons.
- CJC-1295 (no DAC) is the GRF analogue alone, for studies of a single pathway.
- CJC-1295 (DAC) is the DAC-linked version, for comparisons with the no DAC form.
You will find the other reagents in the GH axis category. Calculate your solution concentration in the concentration calculator.
Order the size that fits your study
Choose 5 mg + 5 mg or 10 mg + 10 mg and order by 14:00 to get same-day dispatch. Buy 2 units and get 5% off, 3 units for 10% off, and 5 units for 15% off. The discount is calculated automatically. Orders from 50 EUR (40 GBP, 55 USD) with a peptide vial include 10 ml of bacteriostatic water free of charge. Pay online by card, Apple Pay, Google Pay or BLIK (PLN only).
