Cellular ageing
Cellular Ageing: NAD+, SS-31, Epitalon and More
Reagents for research on telomeres, mitochondria and NAD+.
Cellular ageing is one of the most active areas of laboratory research. Scientists analyse mitochondria, telomeres and cellular energy metabolism. This category brings together eight compounds, each with its own point of interest, which makes them well suited to comparative work.
Eight compounds, eight research directions
| Compound | Structure | Main research focus |
|---|---|---|
| NAD+ | coenzyme (nucleotide) | sirtuins and PARP |
| SS-31 (elamipretide) | synthetic tetrapeptide | cardiolipin and mitochondrial membrane |
| Epitalon | tetrapeptide Ala-Glu-Asp-Gly | telomerase activity |
| N-Acetyl Epitalon Amidate | modified epitalon | molecular stability |
| Humanin | peptide encoded in mitochondrial DNA, 24 amino acids | cytoprotection in models |
| FOXO4-DRI | D-retro-inverso peptide | senolytics, senescent cells |
| PNC-27 | peptide with a membrane-penetrating sequence | cancer cell lines in vitro |
| Teriparatide | fragment 1-34 of parathyroid hormone | clinical studies, registered drug |
NAD+
NAD+ is a coenzyme present in every living cell and central to redox reactions. It serves as a substrate for sirtuins and PARP enzymes, which are studied in the context of DNA repair and metabolic regulation. NAD+ in the shop
SS-31 (elamipretide)
SS-31 binds cardiolipin, a phospholipid of the inner mitochondrial membrane. In in vitro and animal model studies, researchers described its effect on the respiratory chain. SS-31 in the shop
Epitalon
Epitalon is a tetrapeptide with the sequence Ala-Glu-Asp-Gly. In in vitro work, researchers observed its effect on telomerase, the enzyme that maintains telomere length. Epitalon in the shop
N-Acetyl Epitalon Amidate
A modified epitalon with an acetylated N-terminus and amidated C-terminus, designed for greater stability. N-Acetyl Epitalon Amidate in the shop
Humanin
Humanin is a peptide encoded in mitochondrial DNA, within the 16S rRNA region. It consists of 24 amino acids and is studied in cytoprotection models. Humanin in the shop
FOXO4-DRI
FOXO4-DRI is a D-retro-inverso peptide that disrupts the binding of FOXO4 to p53. It is studied as a senolytic in models of ageing cells. FOXO4-DRI in the shop
PNC-27
PNC-27 combines a fragment of the p53-binding protein HDM-2 with a membrane-penetrating sequence. It is studied in vitro on cancer cell models. PNC-27 in the shop
Teriparatide
Teriparatide is a fragment 1-34 of parathyroid hormone and the active substance of the registered drug Forsteo. It has been studied in clinical trials. Teriparatide in the shop
Every batch verified
- Purity 99% or higher, confirmed by HPLC
- Molecular mass confirmed by mass spectrometry (MS)
Details are on our quality page.
Handling in the lab
Store lyophilised material cold and away from light, following the product card. Convert concentrations with our concentration calculator, and find terms in the glossary.
Order with MOLEVIA
Orders placed by 14:00 on a working day ship the same day. In Poland, InPost Paczkomat lockers deliver on the next working day, and across Europe DPD courier delivers in 2-4 working days. Shipping is free from 75 EUR, 65 GBP or 80 USD. Pay online by card, Apple Pay, Google Pay or BLIK (PLN only). Full details are on the shipping page.
Frequently asked questions
What does the Cellular Ageing category include and how is purity checked?
The category brings together eight compounds for comparative work on ageing biology, including NAD+, SS-31, Epitalon, Humanin and FOXO4-DRI. Purity is 99% or higher by HPLC, and molecular mass is confirmed by mass spectrometry (MS).
In what form are these compounds supplied and how should I store them?
Products are supplied as lyophilised material, as stated on each product card. Store the material cold and away from light, following the product card, and work out concentrations with the concentration calculator before you plan an experiment.
How fast does my order ship and how is it delivered?
Orders placed by 14:00 on a business day ship the same day, and later orders ship the next business day. In Poland, an InPost Paczkomat locker delivers on the next business day for PLN 14.99, free from EUR 75. A DPD courier delivers across 29 European countries in 2-4 business days.
Latest from the blog
Senolytic Peptides in Ageing Research: FOXO4-DRI, Humanin and SS-31
How FOXO4-DRI disrupts the FOXO4 and p53 interaction, what humanin does, and how SS-31 binds mitochondrial membrane lipids. A comparison table for labs.
Research overviewNAD+ and SS-31 in Mitochondrial Research: Coenzyme, Cardiolipin and the Respiratory Chain
How NAD+ and SS-31 act in mitochondria: coenzyme role alongside sirtuins, PARP and CD38, cardiolipin binding, and a comparison table of binding points.
Research reviewEpitalon and telomerase research: a literature review
Epitalon (Ala-Glu-Asp-Gly): origin in epitalamin, in vitro telomerase research, animal models and the limits of the evidence.