PNC-27: research overview
What is PNC-27
PNC-27 is a research peptide supplied by MOLEVIA in lyophilised form, a dry powder that is ready for reconstitution in the laboratory. The molecule is produced by chemical peptide synthesis. Its design combines two elements: a fragment of the p53 protein responsible for binding HDM-2, and a membrane-penetrating sequence that helps the peptide enter cells in research models.
This design makes PNC-27 a practical tool for teams working on basic oncology and cell biology. The product is intended exclusively for research use.
Mechanism described in research
The p53 protein acts as a tumour suppressor inside the cell. Its activity is tightly regulated, among other things, by its interaction with HDM-2, a protein that limits the function of p53. The p53 fragment responsible for binding HDM-2 allows researchers to model this interaction under controlled conditions.
In in vitro studies on cancer cell lines, PNC-27 has been described as a tool for analysing this relationship. The membrane-penetrating sequence allows the peptide to cross into cells, so its activity can be observed inside the cell rather than only at the cell surface.
Research areas
- interactions between p53 and HDM-2 in cancer cells
- peptide penetration across the cell membrane in in vitro models
- p53 regulation pathways in basic research
- cell models used in laboratory oncology
Product specification
| Parameter | Value |
|---|---|
| Name | PNC-27 |
| Form | lyophilised powder |
| Purity | 99% or higher (HPLC) |
| Mass | confirmed by MS |
| Available sizes | 5 mg, 10 mg |
| Intended use | research reagent (RUO) |
Working with PNC-27 in the lab
Lyophilised powder
Store the dry powder at -20 °C in a tightly sealed vial. Protect it from moisture and light. Before opening, let the vial reach room temperature.
Solution after reconstitution
Once dissolved, keep the solution at 2-8 °C. Avoid repeated freezing and thawing, because repeated temperature changes reduce the stability of the peptide. For daily work, divide the solution into smaller aliquots.
The role of the solvent
- Bacteriostatic water is the standard solvent for working with lyophilised peptides. We also supply it in a 10 ml vial.
- Diluted acetic acid is used when a peptide dissolves poorly in water. The choice of solvent should always follow the protocol of your study.
Quality of every batch
Each PNC-27 batch goes through analytical control. Purity is measured by HPLC and must reach 99% or higher. Molecular mass is confirmed by mass spectrometry (MS). Results are assigned to a specific batch, so you always know which results apply to the material in your vial.
You can find more about our standards on the quality page.
Ordering and pack sizes
PNC-27 is available in 5 mg and 10 mg vials. When you buy several units, the quantity discount applies automatically: 5% for 2 units, 10% for 3 units and 15% for 5 units. Orders from 50 EUR (40 GBP, 55 USD) that include a peptide vial come with a free 10 ml bacteriostatic water vial. Pay online by card, Apple Pay, Google Pay or BLIK (PLN only).
Before you choose a quantity, check your figures in the concentration calculator.
Related products
Other peptides from the cellular ageing area:
You can browse the full range in the cellular ageing category.
