Gonadorelin: research overview
Gonadorelin is a research reagent for studies of the hypothalamic-pituitary-gonadal axis. At MOLEVIA we supply it as a lyophilized peptide with confirmed purity and mass. This product is sold strictly as a Research Use Only reagent.
What Gonadorelin Is
Gonadorelin is a synthetic decapeptide, a chain of ten amino acids. Its sequence is identical to gonadoliberin, the natural hypothalamic hormone known as GnRH. The molecule starts with a pyroglutamic acid residue and ends with an amidated glycine:
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
Chemical synthesis gives a compound with a repeatable structure, which matters when results must be compared across experiments and models. A short peptide chain also makes quality control easier, because every synthesis and purification step can be verified analytically.
Mechanism Described in Research
Gonadorelin is an agonist of the GnRH receptor found on gonadotroph cells of the pituitary gland. In research models, its action is described as stimulating the release of the gonadotropins LH and FSH.
The literature stresses that the pituitary response depends on the character of the signal. Continuous exposure to an agonist leads to receptor desensitization, which is why laboratories study both short and prolonged exposure patterns. This makes gonadorelin a valuable tool for work on hormonal regulation.
Research Areas
- the hypothalamic-pituitary-gonadal axis in animal models and in vitro studies
- regulation of LH and FSH secretion
- GnRH receptor signalling in cell cultures
- comparisons with GnRH analogues such as triptorelin
- studies on the rhythm of hormone secretion
- the compound has been the subject of clinical investigation, as described in the medical literature
Product Specifications
| Parameter | Value |
|---|---|
| Name | Gonadorelin |
| CAS | 33515-09-2 |
| Formula | C55H75N17O13 |
| Molecular mass | 1182.3 g/mol |
| Form | lyophilized powder |
| Purity | 99%+ (HPLC) |
| Available sizes | 2 mg, 5 mg |
Working in the Laboratory
Store the lyophilized powder at -20 °C in a tightly sealed vial, away from light. After reconstitution, keep the solution at 2-8 °C and avoid repeated freezing and thawing, which shortens the stability of the molecule.
The choice of solvent depends on your experimental plan:
- Water: the primary solvent for gonadorelin. Use water of analytical quality or bacteriostatic water.
- Diluted acetic acid: a secondary solvent for when the peptide dissolves more slowly than expected. Add it in small portions.
Prepare solutions under aseptic conditions and check clarity before use.
Batch Quality
Every batch goes through HPLC analysis, which confirms purity of at least 99%. Mass spectrometry (MS) confirms the molecular mass. Each batch is identified by its batch number, so you can verify the material before starting your work.
When checking a batch, compare three elements: the HPLC purity result, the agreement of the mass with the theoretical value from MS, and the appearance of the lyophilized powder. For repeated series, record the batch number in your documentation so that every result can be assigned to a specific material.
Related Peptides
- Ipamorelin: a secretagogue from the same research family, used in models of the GH axis
- Sermorelin: a GHRH analogue often compared with gonadorelin in studies of hypothalamic signalling
- Triptorelin: a long-acting GnRH analogue, useful for direct comparison with gonadorelin
Browse the full range in the GH axis category, review our quality standards, or calculate your working concentration in the concentration calculator.
