MGF: research overview
What is MGF
MGF, or mechano growth factor, is a peptide that corresponds to the C-terminal fragment of the IGF-1Ec isoform. The Ec isoform arises from alternative splicing of the IGF-1 gene, so MGF belongs to the same genetic family as insulin-like growth factor 1.
Researchers treat MGF as a separate fragment and study it independently of the full IGF-1 molecule. That gives it its own profile in experiments and makes it a distinct research tool rather than a substitute for the parent protein.
Structure and origin
MGF is a peptide chain built from amino acids. Its sequence reflects the end of the Ec isoform. We supply it as a lyophilized powder, a dry form that stores well and makes precise weighing easier when you prepare solutions.
Mechanism described in research
In vitro studies describe MGF as a stimulus for muscle satellite cells, the precursor cells responsible for repairing muscle fibres. Under defined conditions, these experiments report increased proliferation and activation of the cells.
Animal models have been used to examine repair processes after tissue damage. The mechanism is still an active area of research, and results depend on the model, the concentration and the experimental protocol.
Research areas
- muscle tissue repair in in vitro and animal models
- activation and proliferation of muscle satellite cells
- comparative studies of the GH axis and IGF-1 signalling
- tissue recovery processes in comparative experiments
Specifications
| Parameter | Value |
|---|---|
| Name | MGF (mechano growth factor) |
| Category | GH axis |
| Form | Lyophilized powder |
| Purity | ≥ 99% (HPLC) |
| Molecular mass | Confirmed by MS |
| Pack size | 2 mg |
| Origin | C-terminal fragment of the IGF-1Ec isoform |
Working with MGF in the lab
Storage
- Lyophilized powder: -20 °C, tightly sealed, away from moisture and light.
- Reconstituted solution: 2-8 °C.
- Avoid repeated freezing and thawing. Divide the solution into single-use aliquots.
Reconstitution
Water is the basic solvent for laboratory work. If the peptide dissolves poorly in water, a small amount of acetic acid helps bring it into solution before the volume is made up with water. Calculate the final concentration with our concentration calculator before you start.
Batch quality
Every batch is tested by HPLC, which confirms purity at ≥ 99%. Mass spectrometry (MS) confirms the molecular mass. Full details of our testing are on the quality page.
See also
- Quality standards: details of the analyses behind every batch
- Concentration calculator: convert weight into solution concentration
- GH axis category: all products from this research area
- Ipamorelin: a secretagogue from the same research axis
- CJC-1295 no DAC: a GHRH analogue used in GH axis studies
- Sermorelin: a GHRH analogue used in comparative research
