GHRP-2: research overview
What is GHRP-2
GHRP-2, also known as pralmorelin, is a synthetic hexapeptide from the GHRP family, a group of compounds developed as ligands of the ghrelin receptor. The molecule is built from six amino acid residues and carries structural modifications typical of this class, which shape its stability under research conditions. It is produced by chemical synthesis, so every batch can be assessed with the same analytical methods.
Mechanism described in research
GHRP-2 acts as an agonist of the GHS-R1a receptor, also called the ghrelin receptor. In in vitro and animal models, activating this receptor triggers pulsatile release of growth hormone (GH) from the pituitary gland. The pathway works alongside growth hormone releasing hormone (GHRH) signalling, which is why researchers use GHRP-2 to study the whole hypothalamic-pituitary axis and its downstream effects, including IGF-1 signalling.
The substance has also been examined in clinical studies, as the scientific literature describes. At MOLEVIA it is offered exclusively as a research use only (RUO) reagent.
Research areas
- ghrelin receptor GHS-R1a signalling and its ligands
- regulation of growth hormone secretion in in vitro and animal models
- the GH-IGF-1 axis and its links to metabolic signals
- energy homeostasis and appetite regulation in animal models
- comparative studies with other GH secretagogues, such as ipamorelin and sermorelin
Product specifications
| Parameter | Value |
|---|---|
| Name | GHRP-2 (pralmorelin) |
| CAS number | 158861-67-7 |
| Chemical formula | C45H55N9O6 |
| Molecular mass | 817.9 g/mol |
| Form | lyophilized powder |
| Purity | ≥99% (HPLC) |
| Available sizes | 5 mg, 10 mg, 15 mg |
Working with GHRP-2 in the lab
Storage
Keep the lyophilized powder at -20 °C in a tightly sealed vial, away from light and moisture. Once reconstituted, store the solution at 2-8 °C. Avoid repeated freezing and thawing, because each cycle can degrade the peptide.
Reconstitution
- Water: the main solvent. Bacteriostatic or sterile water is used in the lab, and the volume is chosen to reach the working concentration your protocol requires.
- Acetic acid: a diluted solution used as a secondary solvent when the peptide does not dissolve well in water alone.
Batch quality
Each batch undergoes HPLC analysis, which confirms purity of at least 99%. Mass spectrometry (MS) confirms the molecular mass. Read more on our quality page.
Choosing a vial size
The 5 mg, 10 mg and 15 mg vials share the same quality. They differ only in the amount of material. Smaller vials suit single trials, while larger ones fit longer research series. Work out your working volume in the concentration calculator.
Related products
- Ipamorelin, another ghrelin receptor ligand used in GH axis research.
- CJC-1295 no DAC, a GHRH analogue for studies of growth signalling.
- Sermorelin, a GHRH analogue used in comparative research.
Browse the full GH axis category. Order GHRP-2 from MOLEVIA before 2 pm on a working day and it ships the same day.
