Triptorelin: research overview
What is triptorelin
Triptorelin is a synthetic analogue of gonadotropin-releasing hormone (GnRH), the natural decapeptide produced in the hypothalamus. It differs from the native hormone at position 6, where D-tryptophan takes the place of glycine. This change makes the peptide more resistant to enzymatic breakdown, and the literature describes a longer-lasting interaction with the GnRH receptor than the native hormone shows.
Triptorelin 2 mg is supplied to the lab as a high purity lyophilized powder, made by chemical synthesis.
Mechanism described in research
Triptorelin is a GnRH receptor agonist. In cell and animal models, continuous stimulation of the receptor has been reported to cause desensitization, meaning the cell responds less strongly to the same signal over time. This effect is among the most studied mechanisms in research on the hypothalamic-pituitary-gonadal axis. Researchers use it as a reference point when comparing GnRH analogues and measuring intracellular signalling.
Research areas
- Reproductive endocrinology in animal models
- GnRH receptor signalling in pituitary cell cultures
- In vitro models of hormone-dependent cancers
- Receptor desensitization kinetics
- Peptide analysis and LC-MS reference material
Clinical trials and registration
Triptorelin is registered in several countries and has been the subject of numerous clinical trials, as the published literature documents. For a laboratory, this means a well characterized compound with an extensive body of literature on its physicochemical properties and analytical methods. The product is sold strictly as a research reagent.
Specifications
| Parameter | Value |
|---|---|
| Name | Triptorelin |
| CAS number | 57773-63-4 |
| Formula | C64H82N18O13 |
| Molecular mass | 1311.5 g/mol |
| Form | Lyophilized powder |
| Purity | 99% or higher (HPLC) |
| Available sizes | 2 mg |
Working in the lab
Storing the lyophilized powder
Keep the vial at -20 °C, tightly sealed and away from moisture and light. Let it reach room temperature before opening, so that water does not condense on the powder.
Reconstitution and solution storage
High purity water is the basic solvent. Triptorelin contains basic residues, so some protocols add a small amount of acetic acid to aid dissolution. Store the reconstituted solution at 2-8 °C and avoid repeated freezing and thawing. Prepare aliquots sized for a single experiment.
Batch quality
Every batch is checked by HPLC, which confirms purity of 99% or higher. Molecular mass is verified by mass spectrometry (MS), and the results are tied to the batch number. Read more on our quality page.
Related products
- Ipamorelin, a pentapeptide from the GHRP family, studied alongside other GH axis peptides
- Sermorelin, a GHRH analogue used in growth hormone signalling studies
- GHRP-2, a growth hormone secretagogue from the GHRP family
Browse the full GH axis category and calculate solution concentrations with our concentration calculator.
