Semax: research overview
What is Semax
Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. Its N-terminal part corresponds to a fragment of the ACTH hormone, and the three C-terminal residues, Pro-Gly-Pro, were added during the development of the analogue. The molecule originates from Russian research into ACTH fragments.
A short and well-defined sequence makes Semax an easy reference point for research teams. Its molar mass of 813.9 g/mol and its formula, C37H51N9O10S, are confirmed analytically, so every batch matches the same specification. It is supplied as a lyophilised powder that is prepared in the lab using a standard, controlled routine. When working with peptides, record the batch number, the date the solution was prepared and the storage conditions from the start, as this makes later interpretation of results much easier.
Mechanism described in research
In vitro studies have reported effects of Semax on the expression of neurotrophic factors, including BDNF and NGF, in cultures of nerve cells. Animal model studies have described interactions with the dopaminergic and serotonergic systems and with memory-related processes under experimental conditions.
Some of the work also covered protection of nerve cells in models of cerebral ischaemia. The mechanisms are not fully explained and most of the data come from preclinical models, so the published findings are best treated as a starting point for your own controlled experiments.
Research areas
- Neuroprotection in models of ischaemia and nerve tissue injury
- BDNF and NGF expression in in vitro studies
- Learning and memory processes in animal models
- Dopaminergic and serotonergic systems in neuropharmacological research
- Links with melanocortin receptors in experimental work
Product specifications
| Parameter | Value |
|---|---|
| Name | Semax |
| CAS number | 80714-61-0 |
| Formula | C37H51N9O10S |
| Molar mass | 813.9 g/mol |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Form | lyophilised powder |
| Purity | ≥ 99% |
| Sizes | 5 mg, 10 mg, 30 mg |
Laboratory handling
Reconstitution and storage
- Lyophilised powder: store at -20 °C, tightly sealed and protected from light.
- Before opening: let the vial reach room temperature to limit moisture condensation.
- After reconstitution: store the solution at 2-8 °C.
- Freezing: avoid repeated freezing and thawing, and aliquot the solution into smaller portions.
- Solvent: use bacteriostatic water as the laboratory solvent.
Batch quality
Every batch of Semax is analysed by HPLC, which confirms purity of at least 99%. Mass spectrometry (MS) confirms the molecular mass of 813.9 g/mol. The results for that batch number cover both analyses. Read more about our testing routine on the quality page.
In practice, a purity of 99% or higher means that impurities, such as synthesis fragments or by-products, make up only a small share of the material. This matters for research teams, because the reliability of an experiment depends on how precisely the compound is known.
Related research peptides
Also see PE-22-28, Dihexa, Selank and DSIP. Browse the full neuropeptides category, and use the concentration calculator when preparing solutions.
