N-Acetyl Selank Amidate: research overview
What is N-Acetyl Selank Amidate
N-Acetyl Selank Amidate is a modified form of selank, a synthetic heptapeptide derived from tuftsin, a natural tetrapeptide that is a fragment of the immunoglobulin G heavy chain. The core follows the selank sequence, while two terminal modifications change the chemistry of the molecule. The first residue carries an acetyl group on its N-terminus, and the last residue carries an amide group in place of a free carboxyl group at the C-terminus.
Selank was developed in Russia, where it has been studied in clinical research and is registered as a medicine. The acetylated and amidated form is chosen by researchers who want to see how terminal modifications change peptide behavior in their models. For a lab, it is a well-defined molecule with a known sequence, a predictable structure and an identity you can confirm by mass spectrometry.
Mechanism described in research
Free peptide ends are the first target of exopeptidases, enzymes that cut amino acids from the termini of a chain. Acetylating the N-terminus and amidating the C-terminus slow part of this breakdown, which is why these forms are used to compare stability in cell cultures and biochemical assays. The difference matters, because the time a peptide stays intact in solution shapes the outcome of an experiment.
Research on selank focused mainly on neurotransmission, BDNF levels and the metabolism of enkephalins, which are endogenous opioid peptides. Data for the N-acetylated and amidated form are fewer, so treat selank as your reference point and compare results within your own model. Outcomes depend on the experimental system, concentration and exposure time.
Research areas
- Peptide stability against enzymes in in vitro assays
- Neurobiology and neurotransmission in cell models
- BDNF levels and gene expression in cultures
- Enkephalin metabolism in biochemical tests
- Comparisons of analogues with selank and other neuropeptides
Product profile
| Parameter | Value |
|---|---|
| Name | N-Acetyl Selank Amidate |
| Category | Neuropeptides |
| Core sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Modifications | N-terminal acetylation, C-terminal amidation |
| Form | lyophilized powder |
| Purity | ≥ 99% (HPLC) |
| Mass confirmation | mass spectrometry (MS) |
| Available size | 30 mg |
Working in the lab
Storage and reconstitution
- Store the lyophilized powder at -20 °C, tightly closed and protected from light.
- After reconstitution, keep the solution at 2-8 °C.
- Avoid repeated freezing and thawing. Divide the solution into working aliquots so each one is used once.
Solvents
- Bacteriostatic water is the most common solvent in peptide work. It limits microbial growth in the solution, which makes extended work with one vial easier.
- Dilute acetic acid is an option when the peptide dissolves poorly in water. Selank carries basic lysine and arginine residues, so a weak acid aids dissolution. Your own lab protocol sets the final choice.
Before first use, record the reconstitution date, batch number and working concentration. Convert your working concentrations with the concentration calculator.
Batch quality
Every batch goes through HPLC, which confirms purity of at least 99% and shows the impurity profile. Mass spectrometry (MS) confirms the molecular mass. Learn more about our controls on the quality page.
Ordering and delivery
- Orders placed by 2 pm on business days ship the same day.
- In Poland, InPost parcel lockers deliver on the next business day.
- DPD delivers across Europe in 2-4 business days.
- Shipping is free from 75 EUR, 65 GBP, 80 USD.
- Quantity discounts apply automatically in the cart: 5% for 2 pieces, 10% for 3 pieces, 15% for 5 pieces.
- Orders from 50 EUR (40 GBP, 55 USD) with a peptide vial include 10 ml of bacteriostatic water free of charge.
- Pay online by card, Apple Pay, Google Pay or BLIK (PLN only).
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