N-Acetyl Semax Amidate: research overview
What N-Acetyl Semax Amidate is
N-Acetyl Semax Amidate is a modified form of semax, a synthetic peptide developed in Russia. Semax is a heptapeptide derived from a fragment of the ACTH hormone, with a Pro-Gly-Pro tail attached. The N-acetylated version carries two additional modifications: an acetylated N-terminus and an amidated C-terminus. Both changes sit at the ends of the chain, which are the positions where peptidases typically act.
For a laboratory, the key point is that this is a well-defined molecule with a known structure. Every batch can be verified with standard analytical methods.
How it is studied
In vitro and animal model studies have described the effects of semax on the expression of neurotrophic factors, mainly BDNF and NGF. Because semax derives from ACTH, research on the parent peptide also covers melanocortin receptors.
For the N-acetylated version, the central research question is how the terminal modifications change the stability of the peptide in solution and its interaction profile. For this reason, projects often compare it with semax in the same experimental systems.
Semax has been studied clinically and is registered in Russia, as described in the literature. The N-acetylated version remains a subject of laboratory research, so results reported for semax are a useful starting point for your own project.
Research areas
- Neurobiology in cell models
- BDNF and NGF expression in in vitro studies
- Affinity for melanocortin receptors in binding assays
- Models of neuronal damage in cell cultures
- Peptide stability and the effect of end modifications on enzymatic breakdown
Product specification
| Parameter | Value |
|---|---|
| Name | N-Acetyl Semax Amidate |
| Sequence | Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2 |
| Category | Neuropeptides |
| Form | lyophilised powder |
| Purity | ≥ 99% (HPLC) |
| Molecular mass | confirmed by MS |
| Available sizes | 30 mg |
Working in the laboratory
Storage and reconstitution
- Keep the lyophilised powder at -20 °C, tightly sealed and protected from light.
- Once reconstituted, keep the solution at 2-8 °C.
- Avoid repeated freezing and thawing. Divide the solution into working portions so each one is used once.
- Record the reconstitution date, batch number and the concentration you chose. Full documentation makes the experiment repeatable.
Solvent
Water, including bacteriostatic water, is the basic solvent in laboratory work. When the peptide dissolves poorly in water, protocols often call for a small addition of dilute acetic acid, which serves as a secondary solvent. Choose the approach in your own laboratory and convert concentrations with our calculator.
Batch quality
Every batch undergoes HPLC analysis, which confirms purity of at least 99% and shows any impurities. Mass spectrometry (MS) confirms the molecular mass, which verifies the identity of the material.
Ordering
Orders placed by 14:00 on a working day ship the same day. Pay online by card, Apple Pay, Google Pay or BLIK (PLN only). Quantity discounts apply automatically: from 2 pieces 5%, from 3 pieces 10%, from 5 pieces 15%. For orders from 50 EUR (40 GBP, 55 USD) that include a peptide vial, we add 10 ml of bacteriostatic water free of charge. Delivery is free from 75 EUR, 65 GBP or 80 USD.
Related products
- Semax, the classic heptapeptide from the same research line
- Selank, a tuftsin analogue from the neuropeptide group
- N-Acetyl Selank Amidate, an N-acetylated version with an amidated C-terminus
Browse the full range in the neuropeptides category. Batch purity and identity are described on the quality page, and you can convert solution concentrations in the concentration calculator.
