P21: research overview
What is P21
P21 is a peptide derived from ciliary neurotrophic factor (CNTF), a protein that has been studied for years for its effects on nerve cells. The P21 molecule is built on this structural background and carries an adamantyl modification, a chemical group attached to the peptide chain. For research teams this matters, because it allows your own results to be compared with the broad CNTF literature and its signalling biology.
We supply P21 as a lyophilized powder in a 10 mg vial. Every batch is checked for purity and mass. You know exactly what material you are working with from the first day of the study.
Mechanism described in research
In the scientific literature, P21 is described as a peptide linked to CNTF activity. CNTF transmits its signal through a receptor complex built from CNTFRα, gp130 and LIFR, and the signal travels mainly along the JAK/STAT pathway. In cultured neural and progenitor cells, researchers have examined how this kind of stimulation affects cell differentiation and survival.
This makes P21 a practical tool for questions about neurogenesis, the formation of new neurons from precursor cells. A researcher can compare the response of cells to P21 with the response to CNTF itself and in this way separate effects that belong to one specific signalling route.
Research areas
- Neurogenesis in cell culture models
- Neurogenesis in animal models
- Differentiation of neural progenitor cells
- CNTF receptor signalling and the JAK/STAT pathway
Product specification
| Parameter | Value |
|---|---|
| Name | P21 |
| Form | lyophilized powder |
| Purity | ≥ 99% (HPLC) |
| Available sizes | 10 mg |
| Origin | CNTF-derived peptide with adamantyl modification |
| Category | neuropeptides |
Working in the laboratory
Storage
- Lyophilized powder: store at -20 °C, tightly sealed, protected from light and moisture.
- Before opening: let the vial reach room temperature to prevent water from condensing on the powder.
- After reconstitution: keep the solution at 2-8 °C.
- Freezing: avoid repeated freeze and thaw cycles, and divide the solution into smaller aliquots.
Solvent
Bacteriostatic water is the standard solvent for working with lyophilized peptides and you can find it in our range. Dilute acetic acid is used as an auxiliary solvent when the peptide dissolves poorly in water alone. The choice of solvent depends on your research protocol, so check it together with the batch information.
Batch quality
Every batch of P21 is analysed by HPLC, which confirms purity at ≥ 99%. Mass spectrometry (MS) confirms the molecular mass. Synthesis by-products make up only a small share of the material, which makes your results easier to reproduce. Details of our testing procedures are described on the quality page.
Related research peptides
See also PE-22-28, Semax and Selank. Browse the full neuropeptides category. To prepare solutions, use our concentration calculator.
