PE-22-28: research overview
What is PE-22-28
PE-22-28 is a synthetic analogue of a spadin fragment. Spadin is a short peptide that has drawn steady interest from researchers studying ion channels in the nervous system. The molecule is built by controlled chemical synthesis, so composition and purity can be checked batch by batch.
We supply PE-22-28 as a lyophilised powder, ready to be reconstituted in the laboratory. The freeze-dried form keeps the material stable and lets your team prepare a solution in exactly the volume a given experiment requires.
This product is a research reagent, intended for laboratory use only.
Mechanism described in research
Studies describe PE-22-28 as a blocker of the TREK-1 potassium channel. TREK-1 belongs to the two-pore domain (K2P) family of potassium channels and controls how potassium ions move across the cell membrane. Blocking it changes the membrane potential and the excitability of neurons, which is why research teams use PE-22-28 as a tool for questions about signalling in nervous tissue.
Treat the mechanism as a starting point for your experiment. The best projects define a clear research question and build their own control group around it.
Research areas
- Modulation of the TREK-1 channel in in vitro models
- Neuronal excitability and membrane potential in experimental studies
- Animal models of mood disorders and neurological processes
- Comparisons with other neuropeptides in cell cultures
Reagent specification
| Parameter | Value |
|---|---|
| Name | PE-22-28 |
| Category | Neuropeptides |
| Origin | Synthetic analogue of a spadin fragment |
| Form | Lyophilised powder |
| Purity | ≥ 99% (HPLC) |
| Molecular mass | Confirmed by MS |
| Pack sizes | 5 mg, 10 mg |
Laboratory handling
Lyophilised powder
- Store at -20 °C, tightly sealed and protected from light.
- Before opening the vial, let it warm to room temperature to avoid condensation.
Solution after reconstitution
- Store the solution at 2-8 °C.
- Avoid repeated freezing and thawing. If you plan several measurement series, divide the solution into aliquots.
Solvent
Water is the basic solvent in laboratory work and forms the base of most working solutions. Dilute acetic acid helps dissolve some peptides with a basic character. The choice always depends on the research protocol, and your team sets the details.
Batch quality
Every batch of PE-22-28 goes through two checks:
- HPLC: confirms purity of ≥ 99%.
- MS: confirms the molecular mass of the peptide.
This keeps results from one order comparable with the next.
Related products
If you work on neuropeptides, take a look at Selank, Semax and DSIP.
You can also browse the neuropeptides category, read about our quality control and use the concentration calculator to work out your solution before you start.
