AOD-9604: research overview
What is AOD-9604
AOD-9604 is a synthetic peptide corresponding to fragment 176-191 of the growth hormone chain, with an additional tyrosine at the N-terminus. The molecule consists of 16 amino acid residues, and two cysteines form a disulfide bridge that stabilises its structure.
Full growth hormone is a large protein with a complex range of activities. Studying an isolated fragment allows a research question to be narrowed to one well-defined part of the molecule, which is why AOD-9604 is a frequently chosen compound in metabolic research.
Mechanism described in research
In vitro studies have observed the effect of the fragment on lipid metabolism in cultured adipose tissue cells. Animal model studies have described that, unlike full growth hormone, the fragment was not associated with an increase in IGF-1, the insulin-like growth factor 1.
The substance has also been the subject of clinical studies, and its mechanism remains an area of active scientific discussion. Most of the available data come from preclinical models, so they are best treated as a starting point for your own research design.
Areas of research
- Lipid metabolism in in vitro models
- Lipolysis and lipogenesis in cell cultures
- IGF-1-independent activity of growth hormone fragments in animal models
- Cellular energy metabolism in preclinical experiments
- Structural analysis of growth hormone fragments in comparative work
Product profile
| Parameter | Value |
|---|---|
| Name | AOD-9604 |
| CAS number | 221231-10-3 |
| Formula | C78H123N23O23S2 |
| Molecular mass | 1815.1 g/mol |
| Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe |
| Form | lyophilised powder |
| Purity | ≥ 99% (HPLC) |
| Variants | 2 mg, 5 mg, 10 mg |
Working in the laboratory
Reconstitution and storage
| Form | Temperature | Guidance |
|---|---|---|
| Lyophilised powder | -20 °C | Tightly sealed, protected from light |
| Solution after reconstitution | 2-8 °C | Use within the period set by your laboratory protocol |
| Repeated freezing | avoid | Divide the solution into aliquots to limit freeze-thaw cycles |
Let the vial reach room temperature before opening it. Choose the solvent to suit your planned experiment, for example bacteriostatic water, which is widely used as a solvent in laboratory work.
Batch quality
- HPLC: purity of at least 99%
- MS: confirmation of the molecular mass of 1815.1 g/mol
Each batch is identified by its batch number, so you can trace the parameters of the material used in a given experiment and compare them with later deliveries.
See also
- Ipamorelin, a peptide from the same growth hormone axis research area
- Tesamorelin, a GHRH analogue described in the clinical literature
- Sermorelin, a GHRH fragment used in comparative studies
- MOTS-c, a peptide from the same metabolic research category
- SLU-PP-332, a small molecule studied as an ERR receptor agonist
Read how we verify every batch on our quality page, and use the concentration calculator to work out solution concentrations.
