Tirzepatide: research overview
What is tirzepatide
Tirzepatide is a synthetic peptide built from 39 amino acids. A C20 fatty acid chain is attached to its structure, which sets this molecule apart from classic peptides and shapes how it behaves in solution. Tirzepatide is a registered medicine and appears in the literature under the brand names Mounjaro and Zepbound.
The molecule belongs to the incretin analogue family, compounds that mimic hormones released in the gut after a meal. It is one of the most actively studied areas of metabolic pharmacology, and tirzepatide holds a special place in it because it acts on two receptors at once.
Mechanism described in research
Tirzepatide is a dual agonist of the GIP and GLP-1 receptors. It activates two receptors that form part of the incretin axis. In in vitro work and animal models, researchers described its effects on cell signalling in the pancreas and on glucose homeostasis. Models also showed changes in body weight, which is why tirzepatide is often used as a reference point in comparisons with other agonists.
Tirzepatide was the subject of an extensive clinical research programme and is registered as a medicine, which is why it appears often in review literature.
Research areas
- Signalling through GIP and GLP-1 receptors in cell models
- Glucose homeostasis in preclinical studies
- Body weight regulation in animal models
- Lipid metabolism in in vitro work
- Comparisons with other incretin receptor agonists
Reagent specification
| Parameter | Value |
|---|---|
| Name | Tirzepatide |
| CAS number | 2023788-19-2 |
| Molecular formula | C225H348N48O68 |
| Molecular mass | 4813.5 g/mol |
| Form | lyophilized powder |
| Purity | ≥ 99% (HPLC) |
| Available sizes | 5, 10, 15, 20, 30, 40, 50, 60, 80, 100 and 120 mg |
Working in the laboratory
Store the lyophilized powder at -20 °C. After reconstitution, keep the solution at 2-8 °C and avoid repeated freezing, because repeated freezing degrades the peptide over time.
Role of the solvent
- Bacteriostatic water dissolves the lyophilized powder into a working solution, and its preservative keeps microbial growth in a multi-use vial under control.
- Dilute acetic acid is used when the research protocol calls for an acidic environment to dissolve the molecule.
Orders from 50 EUR (40 GBP, 55 USD) that include a peptide vial also receive 10 ml of bacteriostatic water free of charge.
Quality of every batch
- HPLC confirms purity of at least 99%
- Mass spectrometry (MS) confirms the molecular mass of 4813.5 g/mol
Orders and shipping
Orders placed by 14:00 on a business day ship the same day. InPost parcel lockers in Poland deliver the next business day, and DPD serves 29 European countries in 2-4 business days. Pay online by card, Apple Pay, Google Pay or BLIK (PLN only). Shipping is free from 75 EUR, 65 GBP, 80 USD.
See also
- Retatrutide, another compound from the same research family
- Semaglutide, a classic GLP-1 receptor agonist used in comparative studies
- Tirzepatide with cagrilintide, a set for research into combined pathways
Explore more reagents in the incretin analogues category. We describe quality control on the quality page, and you can convert solution concentrations with the concentration calculator.
