Retatrutide: research overview
What is retatrutide
Retatrutide (LY3437943) is a synthetic peptide built from about 39 amino acids, with a lipid chain attached to its structure. This modification sets it apart from classic linear peptides and shapes how the molecule behaves in solution.
The compound belongs to the incretin analogue group, molecules that mimic the gut hormones responsible for regulating blood glucose. Retatrutide comes from a research programme run by Eli Lilly, and its structure is well described in the scientific literature.
Mechanism described in research
Retatrutide is a triple agonist. It activates GIP, GLP-1 and glucagon receptors at the same time, and each of them triggers cAMP-dependent cell signalling. Combining three pathways makes the molecule a subject of research into the regulation of carbohydrate and energy metabolism.
Phase 2 and phase 3 clinical studies described the effects of retatrutide on glycaemia and body weight. Preclinical research models continue to examine how these three receptors work together.
Research areas
- signalling of GIP, GLP-1 and glucagon receptors in cell models (in vitro)
- glucose homeostasis and insulin secretion in animal models
- energy balance and body weight in research models
- comparisons with other incretin analogues, such as tirzepatide and semaglutide
- analytics of peptides carrying long lipid chains
Product specifications
| Parameter | Value |
|---|---|
| Name | Retatrutide (LY3437943) |
| CAS number | 2381089-83-2 |
| Formula | C221H342N46O68 |
| Molecular mass | 4731.3 g/mol |
| Form | lyophilized powder |
| Purity | ≥ 99% (HPLC) |
| Vial sizes | 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 100 mg |
| Category | incretin analogues |
Working in the laboratory
Store the lyophilized powder at -20 °C, tightly sealed and protected from light. Before opening a vial, let it reach room temperature so that moisture does not condense inside.
After reconstitution, keep the solution at 2-8 °C. Avoid repeated freezing and thawing, because repeated temperature changes shorten the stability of the peptide.
The solvent is bacteriostatic water, which can be added to your order. The concentration calculator in the shop will help you work out the numbers.
Quality of every batch
Each batch undergoes HPLC testing, which confirms purity of at least 99%, and MS analysis, which confirms the molecular mass. The results are assigned to the batch number, so you can compare orders and document the material in your project.
Order retatrutide from MOLEVIA
MOLEVIA supplies retatrutide exclusively as a research reagent (Research Use Only). Orders placed by 2 pm on a working day ship the same day. Shipping is free on orders from 75 EUR, 65 GBP, 80 USD, and orders from 50 EUR (40 GBP, 55 USD) that include a peptide vial receive 10 ml of bacteriostatic water as a gift. Volume discounts apply automatically. Pay online by card, Apple Pay, Google Pay or BLIK (PLN only).
Related products
- Tirzepatide as a GIP and GLP-1 analogue for comparison within the same research group
- Semaglutide as a GLP-1 analogue for studies of receptor signalling
- Retatrutide with cagrilintide for research on the combination of two substances
Browse all incretin analogues in one place. Batch parameters are on the quality page, and you can convert concentrations in the concentration calculator.
