Tirzepatide + Cagrilintide: research overview
What tirzepatide with cagrilintide is
Tirzepatide with cagrilintide is a blend of two synthetic peptides supplied together in one lyophilized vial. Each vial contains 10 mg of tirzepatide and 10 mg of cagrilintide, so both compounds are ready for work within the same research setup.
Tirzepatide is a 39-amino-acid peptide with a C20 fatty acid chain attached, and it belongs to the incretin analogue family. Cagrilintide is an analogue of amylin, a peptide hormone whose effects on gastric emptying and on signalling in the central nervous system have been described in the literature.
Both peptides are produced by chemical synthesis rather than from biological material. Tirzepatide is approved as a medicine and went through an extensive clinical research programme. Cagrilintide has also been studied in clinical programmes. This information comes from published literature and does not relate to any use of this reagent.
Mechanism described in research
The blend brings together three signalling pathways. Tirzepatide activates the GIP and GLP-1 receptors, while cagrilintide acts on the amylin receptor. In vitro and animal model studies have described how these pathways influence cell signalling, glucose homeostasis and body mass in models.
Combining the components in one material makes it possible to study how they interact within a single experiment, rather than comparing separate compounds across separate series. This setup suits metabolic models in which several hormones act in parallel.
Research areas
- Signalling of GIP, GLP-1 and amylin receptors in cell models
- Glucose homeostasis in preclinical studies
- Regulation of body mass in animal models
- Lipid and energy metabolism in in vitro work
- Comparisons of the blend with its individual components
Reagent specifications
| Parameter | Value |
|---|---|
| Name | Tirzepatide with cagrilintide (tirzepatide + cagrilintide) |
| Composition | tirzepatide 10 mg + cagrilintide 10 mg |
| Form | lyophilized powder |
| Purity | ≥ 99% (HPLC) |
| Available formats | 10 mg + 10 mg, one format per vial |
Working in the laboratory
Store the lyophilized powder at -20 °C, tightly sealed and protected from light. After reconstitution, keep the solution at 2-8 °C and avoid repeated freezing and thawing, because repeated temperature changes degrade peptides over time.
The role of the solvent
- Bacteriostatic water dissolves the powder into a working solution. Its preservative limits microbial growth in a multi-use vial.
- Dilute acetic acid is used when the research protocol calls for an acidic environment to dissolve the blend.
Orders from 50 EUR (40 GBP, 55 USD) that include a peptide vial also receive 10 ml of bacteriostatic water free of charge.
Quality of every batch
- HPLC confirms purity of at least 99%
- Mass spectrometry (MS) confirms the mass of both peptides in the batch
Ordering and shipping
Orders placed by 14:00 on a business day ship the same day. InPost parcel lockers in Poland deliver the next business day, and DPD serves 29 European countries in 2-4 business days. Pay online by card, Apple Pay, Google Pay or BLIK (PLN only). Shipping is free from 75 EUR, 65 GBP or 80 USD.
See also
- Tirzepatide, the tirzepatide component sold in its own vial
- Cagrilintide, an amylin analogue for comparative studies
- Retatrutide with cagrilintide, another combination of pathways in a single material
Browse more reagents in the incretin analogues category. We describe quality control methods on the quality page, and you can convert solution concentrations with the concentration calculator.
