Cagrilintide: research overview
What cagrilintide is
Cagrilintide is a long-acting analogue of amylin, a peptide hormone released together with insulin by the beta cells of the pancreas. It is a synthetic peptide designed as a modification of natural amylin, which is why its activity in research models lasts longer than that of the native hormone.
We supply cagrilintide as a research reagent in lyophilized form, ready to be reconstituted in the laboratory. Research teams work with material of known purity and confirmed mass, which makes it easier to repeat results from one series of experiments to the next.
Mechanism described in research
Cagrilintide acts as an agonist of amylin receptors. These receptors are formed by the calcitonin receptor combined with RAMP proteins, and their activation triggers intracellular signalling in several cell types.
In vitro studies have described signalling after amylin receptor activation. In animal models, researchers have observed links to glucose homeostasis, food intake and body weight. The broadest body of data comes from preclinical work. Cagrilintide has also been studied clinically, both on its own and in combination with semaglutide in the CagriSema programme.
Research areas
- Amylin and calcitonin receptor signalling in in vitro models
- Glucose homeostasis in studies on animal models
- Regulation of food intake and body weight in experimental models
- Combinations with other incretin analogues as a direction of clinical research
- Shared mechanisms of incretin analogues in metabolic research
Product specifications
| Parameter | Value |
|---|---|
| Name | Cagrilintide |
| Category | Incretin analogues |
| Form | lyophilized powder |
| Purity | 99% or higher (HPLC) |
| Mass confirmation | mass spectrometry (MS) |
| Available sizes | 2 mg, 5 mg, 10 mg, 20 mg |
Working in the laboratory
Storage
- Lyophilized powder: store at -20 °C, tightly sealed and protected from light.
- After reconstitution: keep the solution at 2-8 °C.
- Freezing: avoid repeated freezing and thawing, and divide the solution into smaller aliquots.
- Before opening: let the vial reach room temperature to limit moisture condensation.
Solvent
In laboratory work, sterile bacteriostatic water is the solvent. Carry out reconstitution according to the procedures in force in your laboratory. Once the solution is prepared, label it with the date and batch number so you always know which vial it came from. Orders of 50 EUR (40 GBP, 55 USD) or more that include a peptide vial also receive 10 ml of bacteriostatic water free of charge.
Batch quality
Every batch is tested by HPLC, which confirms purity of at least 99%. We verify the molecular mass by mass spectrometry (MS). Each batch is identified by its batch number, so every test result can be matched to a specific vial.
Related products
- Retatrutide for research, a triple agonist of GLP-1, GIP and glucagon receptors
- Tirzepatide for research, a dual agonist of GLP-1 and GIP receptors
- Cagrilintide with semaglutide, a combination studied clinically
Browse the other analogues in the incretin analogues category. You can read about quality control on the quality page, and convert solution concentrations with the concentration calculator.
