Mazdutide: research overview
What is mazdutide
Mazdutide is a synthetic peptide from the incretin analogue family, a group of compounds that mimic hormones released in the gut after a meal. The molecule is also known in the literature as IBI362 and LY3305677. It was designed to bind two receptors at the same time, which sets it apart from classic GLP-1 agonists.
Mazdutide is a frequent subject of work in metabolic pharmacology. For researchers it is a useful reference point, because it combines activity at the GLP-1 and glucagon receptors, two pathways that research models usually examine side by side.
Mechanism described in research
Mazdutide is a dual agonist of the GLP-1 and glucagon receptors. The GLP-1 receptor takes part in insulin secretion signalling, while the glucagon receptor influences energy handling in the liver and adipose tissue. In in vitro work and animal models, researchers have described how this signalling affects glucose homeostasis and body mass.
Mazdutide has been studied in clinical trials, and the results are described in the scientific literature. This information concerns published research and does not indicate how the reagent should be used.
Research areas
- Signalling through GLP-1 and glucagon receptors in cell models
- Glucose homeostasis in preclinical studies
- Body mass and energy metabolism in animal models
- Lipid metabolism in in vitro research
- Comparisons with other incretin and glucagon receptor agonists
Reagent specifications
| Parameter | Value |
|---|---|
| Name | Mazdutide (mazdutide) |
| Research codes | IBI362, LY3305677 |
| Form | lyophilized powder |
| Purity | ≥ 99% (HPLC) |
| Available sizes | 5 mg, 10 mg |
Working in the laboratory
Store the lyophilized powder at -20 °C, tightly sealed and protected from light. Once reconstituted, keep the solution at 2-8 °C and avoid repeated freezing. Every repeated freezing and thawing reduces the stability of the peptide, which directly affects how reliable your results are.
Choosing a solvent
- Bacteriostatic water dissolves the powder into a working solution. Its preservative slows microbial growth in a multi-use vial.
- Dilute acetic acid is used when the research protocol calls for an acidic environment to dissolve the molecule.
The solvent always follows the planned experiment. Prepare the solution shortly before use.
Quality of every batch
- HPLC confirms purity of at least 99%
- Mass spectrometry (MS) confirms the molecular mass of the batch
Both the 5 mg and 10 mg vials carry the same purity and identity specification, because they are the same product in a different amount.
Why buy from MOLEVIA
Mazdutide from MOLEVIA is a confident choice for research teams working on GLP-1 and glucagon receptor analogues.
- Purity of 99% or higher (HPLC) and mass confirmed by MS
- Same-day dispatch for orders placed by 14:00 on a business day
- Free shipping from 75 EUR, 65 GBP, 80 USD
- Quantity discount applied automatically: 2 pcs -5%, 3 pcs -10%, 5 pcs -15%
- 10 ml bacteriostatic water free with orders from 50 EUR (40 GBP, 55 USD) that include a peptide vial
- Pay online by card, Apple Pay, Google Pay or BLIK (PLN only).
See also
- Survodutide, another compound with dual action on the GLP-1 and glucagon receptors
- Retatrutide, a triple agonist studied within the same compound family
- Tirzepatide, a dual GIP and GLP-1 agonist from the same analogue family
Browse more reagents in the incretin analogues category. Quality control methods are described on the quality page, and you can convert solution concentrations in the concentration calculator.
