Dulaglutide: research overview
What dulaglutide is
Dulaglutide is a fusion protein. It combines a GLP-1 analogue with an Fc fragment from an IgG4 antibody. This design sets it apart from short peptides: the molecule is larger, and its structure makes it possible to compare fusion proteins with peptides from the same family.
Dulaglutide is made by biotechnological methods. It is the active substance of the registered medicine Trulicity, and its properties have been studied in clinical trials. This comes from published literature. In our shop, dulaglutide is supplied strictly as a research reagent.
Mechanism described in research
Dulaglutide acts as a GLP-1 receptor agonist. In vitro studies have described its binding to the receptor and the signalling pathways it triggers in cultured pancreatic beta cells. In animal models, GLP-1 signalling was shown to influence glucose-dependent insulin secretion and glucagon release. Researchers have also described effects on the rate of gastric emptying and on central nervous system centres that regulate energy balance and body mass.
The Fc element affects how long the molecule persists in a model organism. This makes dulaglutide a convenient subject for studies on the stability of fusion proteins.
Research areas
- GLP-1 receptor and cellular signalling in in vitro cultures
- Glucose homeostasis in animal models
- Insulin and glucagon secretion in comparative studies
- Energy balance and body mass in preclinical models
- Fc-fused proteins in stability research
Product specifications
| Parameter | Value |
|---|---|
| Name | Dulaglutide (dulaglutide) |
| Category | Incretin analogues |
| Class | GLP-1 receptor agonist, fusion protein with IgG4 Fc fragment |
| Form | Lyophilized |
| Purity | ≥ 99% (HPLC) |
| Molecular mass | Confirmed by MS |
| Available sizes | 5 mg, 10 mg |
Working in the laboratory
Lyophilized material
Store the lyophilized material at -20 °C, tightly closed and protected from light. Before opening a vial, let it reach room temperature so that moisture does not condense on the substance.
Reconstitution and solution
Choose the solvent to match your planned experiment. In laboratory work you will typically use:
- bacteriostatic water, as the main solvent for preparing a solution,
- acetic acid, as a supporting solvent for peptides with limited solubility in water.
Keep the finished solution at 2-8 °C. Avoid repeated freezing and thawing, and divide larger quantities into portions. Work out the concentration with our concentration calculator.
| Form | Temperature | Notes |
|---|---|---|
| Lyophilized | -20 °C | Tightly closed, protected from light |
| Solution | 2-8 °C | No repeated freezing, divide into portions |
Batch quality
Every batch goes through HPLC analysis, which confirms purity of at least 99%. Mass spectrometry (MS) confirms the molecular mass. Each batch is identified by its batch number. Details of our procedures are on the quality page.
Related products
- Tirzepatide for comparisons of GLP-1 and GIP receptor signalling
- Retatrutide as a triple receptor agonist
- Semaglutide as a classic GLP-1 analogue
Browse the full range in the incretin analogues category.
Order the reagent
Orders placed by 14:00 on business days ship the same day. Pay online by card, Apple Pay, Google Pay or BLIK (PLN only). Orders from 50 EUR (40 GBP, 55 USD) that include a peptide vial come with 10 ml of bacteriostatic water at no charge. Volume discounts apply automatically: 5% for 2 units, 10% for 3 and 15% for 5. Free delivery from 75 EUR, 65 GBP, 80 USD.
