KLOW (BPC-157 + TB-500 + GHK-Cu + KPV): research overview
What KLOW is
KLOW is a ready-made blend of four compounds in a single lyophilised vial, supplied for laboratory research. It combines BPC-157, TB-500, GHK-Cu and KPV, so a research team can study several peptides from the tissue research field in one experiment without weighing each component separately.
BPC-157 is a pentadecapeptide, a chain of 15 amino acid residues, described as a fragment of a protein found in gastric juice. TB-500 is a compound related to thymosin beta-4, an actin-binding protein. GHK-Cu is a copper complex of the Gly-His-Lys tripeptide, and KPV is the Lys-Pro-Val tripeptide, a fragment of the C-terminal end of alpha-MSH.
Mechanism described in research
Each component of KLOW has been studied in a different setting, which makes the blend a practical tool for working along several pathways at once.
- BPC-157: in vitro studies have described effects on the migration and proliferation of fibroblasts and endothelial cells. Animal models have linked the compound to the formation of new blood vessels.
- TB-500: cell culture studies have described effects on cell migration and on the dynamics of the actin cytoskeleton.
- GHK-Cu: in vitro and skin model studies have described effects on collagen synthesis and on remodelling of the extracellular matrix.
- KPV: models of intestinal inflammation and cell culture studies have described reduced pro-inflammatory signalling, including inhibition of NF-kB activation.
Research areas
- Repair processes in soft tissues and tendons in in vitro models
- Angiogenesis and tissue vascularisation in experimental studies
- Extracellular matrix and skin remodelling in dermal models
- Inflammatory processes in models of intestinal inflammation
- Cell migration and cytoskeleton organisation in cell culture
Product specification
| Parameter | Value |
|---|---|
| Name | KLOW (BPC-157 + TB-500 + GHK-Cu + KPV) |
| Content per vial | BPC-157 10 mg, TB-500 10 mg, GHK-Cu 50 mg, KPV 10 mg |
| Category | tissue research |
| Form | lyophilised powder |
| Purity | 99% or higher (HPLC) |
| Mass confirmation | mass spectrometry (MS) |
| Available size | 10 + 10 + 50 + 10 mg, one vial |
Working in the laboratory
Storage and reconstitution
- Lyophilised powder: store at -20 °C, tightly sealed and protected from light.
- Before opening: let the vial reach room temperature to limit moisture condensation.
- Solvent: bacteriostatic water is the most common choice in research. Water with acetic acid is an alternative where the protocol calls for it. Choose the solvent to suit your experimental design before you start.
- After reconstitution: keep the solution at 2-8 °C.
- Freezing: avoid repeated freezing and thawing, and divide the solution into smaller portions.
Batch quality
Every KLOW batch is tested by HPLC, which confirms purity of at least 99%. Mass spectrometry (MS) confirms the mass of the components. Each batch is identified by its batch number, so you know exactly what reaches your laboratory.
Related products
- BPC-157 for research, a single component of the blend, available in 2, 5, 10 and 20 mg
- TB-500 for research, the second component of KLOW, available in 2, 5 and 10 mg
- GLOW, a blend of BPC-157, TB-500 and GHK-Cu without KPV, useful for comparing compositions
You can also browse other tissue research reagents, review our quality page, or use the concentration calculator to work out the solution for your chosen solvent volume.
